equipoise

Antianginal and antihypertensive equipoise activity. Inhibits the flow of calcium ions into cardiac myocytes and vascular smooth muscle cells. It relaxes smooth muscles of coronary and peripheral arteries. Expanding peripheral vessels, reducing peripheral resistance and afterload on the heart. Increase coronary blood flow, reducing myocardial oxygen demand. When taken twice daily Kaltsigard equipoise Retard provides control high blood pressure for 24 hours. Kaltsigard Retard lowers blood pressure so that its percentage decrease is directly related to the original value. In patients with normal blood pressure Kaltsigard Retard generally has little or no effect on blood pressure.

After oral administration Kaltsigard equipoise Retard completely absorbed from the gastrointestinal tract. After a single dose of the drug is gradually controlled by increasing its concentration in blood plasma, which is retained with slight variations to the next through the drug 12 hours. Almost completely metabolized in the liver to inactive metabolites. 60% -80% of nifedipine as metabolites excreted in urine. The half-life is approximately 2 hours. Less than 0.1% of the drug found in the urine unchanged rest excreted in the feces as metabolites. The pharmacokinetics of the drug may vary in patients with chronic liver disease.

 

Contraindications

Hypersensitivity to nifedipine, a equipoise dihydropyridine derivative other or to other components of the formulation; hypotension, cardiogenic shock, collapse, marked aortic stenosis, sick sinus syndrome, angina unstable, severe heart failure, acute phase of myocardial infarction (during the first 4 weeks), pregnancy, lactation.

special instructions

Caution should be exercised when administering the drug Kaltsigard Retard in patients with arterial hypertension, heart failure decompensation, impaired liver and kidney function. A small percentage of patients have chest pain after 30-60 min after administration Kaltsigarda Retard. Although the effect of “steal” has not been found, patients who experience increased angina symptoms should discontinue treatment Kaltsigardom Retard. For patients with diabetes dose should be individualized diabetes.
Not recommended for use in children under 18 years. When you remove the drug dose is reduced gradually in order to prevent the development of “withdrawal syndrome”. During treatment should refrain from drinking alcohol. With care prescribe a drug transport drivers and other occupations that require rapid psychomotor reactions.

Dosing and Administration

Dosage is determined individually. The average dose is 1 tablet (20 mg) twice a day with a small amount of liquid during or after a meal. In case of insufficient clinical response to gradually increasing the dose. The maximum dose is 40 mg twice daily.

Side effect

Since the cardiovascular system: possible – facial flushing, feeling of fever, tachycardia, peripheral edema, hypotension.

Special instructions:

in some patients, especially at the equipoise beginning of treatment, angina pectoris attacks may occur, which requires discontinuation of the drug, the part of the central nervous system: headache, dizziness, fatigue, drowsiness. When using high doses of the drug are marked individual cases of paresthesia of limbs, tremor, disorders of the lungs, sleep disturbance, the part of the gastrointestinal tract and liver: nausea, constipation, diarrhea. Chronic administration of the drug cases increased activity of “liver” transaminases in blood serum can be observed occurrence of intrahepatic cholestasis; Hematopoietic system:rarely – reversible thrombocytopenia, leukopenia, anemia, From the urinary system: an increase in daily urine; in patients with renal insufficiency – renal impairment; Allergic reactions: seldom – rash, itchy skin; Other: long-term use – myalgia, gynecomastia, gingival hyperplasia, hyperglycemia.

Interaction with other drugs

In an application Kaltsigarda and Retard:

 

  • beta-blockers, other antihypertensive drugs, tricyclic antidepressants, diuretics, vasodilators – enhanced hypotensive effect of the drug;
  • in combination with nitrates observed tachycardia and increased hypotensive effect; diltiazem – the clearance of nifedipine is reduced. By using such a combination is necessary to reduce the dose Kaltsigarda Retard and carefully monitor the patient;
  • antiarrhythmic drugs (eg amiodarone and quinidine) – can amplify their negative inotropic effect;
  • digoxin reduced clearance of digoxin, increases level of digoxin in plasma and the risk of developing digoksinovoy intoxication. In these cases it is necessary to reduce the dose of digoxin and check its level in blood plasma;
  • theophylline may increase plasma theophylline levels that require dose correction;
  • cimetidine and, to a lesser extent, ranitidine may increase the plasma level of nifedipine and intensify its action;
  • vincristine difficult removal of the last of the body, which increases the risk of increasing the side effects of vincristine;
  • cephalosporins increased bioavailability of cephalosporins.

Overdose

Symptoms: severe hypotension, cardiac arrhythmias (bradycardia or tachycardia). With an increase in the phenomena of intoxication can occur hypoxia, cardiogenic shock, impaired consciousness.Treatment : gastric lavage, activated charcoal, intravenous administration of calcium salts. Treatment is symptomatic. Hemodialysis is not effective.

release Form

10 tablets in a blister made ??of PVC film and aluminum foil. 3 blisters or 10 blisters with instruction for use in a cardboard box.
The sample is not for sale: 4 tablets or 10 tablets in a blister made ??of PVC film and aluminum foil. 1 blister with instruction on use is packed in a cardboard box.

Storage conditions

Store at temperatures below 30 ° C, protected from light and moisture.
Keep out of reach of children

Shelf life :. 3 years from date of manufacture
Do not use after the date printed on the packaging.

Conditions of supply of pharmacies : Prescription nandrolone fenilpropionato

equipoise only cycle

 

Combined preparation containing vitamins, micro and macro; effect due to the properties included in the ingredients.Prevention and comprehensive treatment of osteoporosis of various origins:women in menopause (natural or surgical);for persons equipoise only cycle receiving long-term steroids and immunosuppressants.Treatment of diseases of the musculoskeletal system: to improve the consolidation of traumatic fractures.To make up for deficiency of calcium and trace elements in adolescents.Individual hypersensitivity to any of the ingredients of the drug, kidney stones, hypercalcemia and hypercalciuria, children’s age (12 years).

Dosage and administration.
Inside. Adults and children equipoise only cycle (over 12 years) – 1 tablet twice a day with meals.

Side effects.
Nausea, vomiting, flatulence, hypercalcemia and hypercalciuria, allergic reactions.

Overdose.
Symptoms: constipation, nausea and vomiting, hypercalcemia and hypercalciuria.

Special instructions.
The dose should not exceed that which is specified in the instructions, as increased intake of calcium can inhibit the intestinal absorption of iron, zinc and other essential minerals.
Nursing women should be aware that cholecalciferol and its metabolites into breast milk.
During pregnancy and during lactation the drug should be discussed with your doctor. At deficiency of equipoise only cycle calcium and mineral supplements recommended dose of 1 tablet per day.

Product form.
By 30, 60 and 120 in round tablets White bottles of high density polyethylene. Polypropylene vial cap sealed with a protective film. Bottle with instruction on the medical application is placed in a cardboard box.

Shelf life.
3 years. Do not use beyond the expiration date printed on the package.

Storage conditions.
In dry, out of reach of children equipoise only cycle, at a temperature of 15 – 30 ° C.

Vacation pharmacy.
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clinical equipoise

Tablets kapsulovidnoy elongated shape, coated white, with embossed on one side of the notch. Combined preparation containing vitamin DZ, micro- and macronutrients. Regulates calcium and phosphorus metabolism, makes up for clinical equipoise the relative shortage of micronutrients and vitamin DZ, prevents diseases of the musculoskeletal system, helps to strengthen the skeletal system and joints.Prevention and comprehensive treatment of osteoporosis of various origins:To make up for deficiency of calcium and trace clinical equipoise elements in adolescents, women during pregnancy and breastfeeding.

 

Dosage and administration.

Adults and children after 12 years of one pill 2 times per day with meals. During pregnancy and breast-feeding to the 20th week of pregnancy and the entire lactation, 1 tablet 2 times a day. Children from 5 to 12 years of use 1 tablet 1 time per day during clinical equipoise the meal. At deficiency of calcium and trace elements recommended dose – 1 tablet per day.

Side effect

In rare cases: nausea, vomiting, flatulence, hypercalcemia and hypercalciuria, allergic reactions.

Overdose

When possible overdose clinical equipoise constipation, nausea, and vomiting. The manifestation of an overdose also include hypercalcemia and hypercalciuria, leading to the accumulation of calcium in the soft tissue and irreversible changes in the kidneys and cardiovascular system.

special instructions

The dose should not exceed that which is specified in the instructions, as increased intake of calcium can inhibit the intestinal absorption of iron, zinc and other essential minerals.

Use during pregnancy and breast-feeding

During pregnancy and breast-feeding the drug to agree with the doctor.

Breastfeeding women should clinical equipoise be aware that cholecalciferol and its metabolites into breast milk.

release Form

Coated tablets.

At 30, 60 or 120 tablets in a bottle HDPE with screw cap made of polypropylene, sealed film. Each vial with instruction on the medical application is placed clinical equipoise in a cardboard box.

Storage conditions

In dry, the reach of children, at a temperature of 15 – 30 ° C.

Shelf life

3 years. Do not use after the expiration date printed on the packaging.

Holiday from drugstores

Without recipe. geneza pharmaceuticals for sale

equipoise results

The action equipoise results of this drug due to its integrated components. Methenamine relates to a class of antiseptics and disinfectants, to the aldehyde group. The action of the drug based on the ability to decompose in an acidic medium to give formaldehyde, which in this case has antiseptic and anti-inflammatory properties.Integrated methenamine salt is present to make up for deficiency of calcium ions, to reduce vascular permeability (which is typical for any inflammation).Symptomatic treatment of acute respiratory equipoise results diseases and “common cold” diseases (in the complex therapy). The drug should be an adult with the initial symptoms of a cold.

Contraindications:
Hypersensitivity, hypoacid gastric, hepatic failure, chronic renal failure, pregnancy, lactation, children’s age.

Dosing and Administration
Inside, 1-2 tablets 3-4 times a day. The course of treatment – 3-5 days.

Side effects
are possible dyspepsia, stop when they appear, taking the drug.

Overdose Symptoms: a sharp irritation of the conjunctiva and mucous membranes of the respiratory tract, dyspepsia (nausea, vomiting, diarrhea), glomerulonephritis. Treatment: The recommended intake of thioctic acid, folic acid, ascorbic acid, pyridoxine equipoise results and nicotinic acid preparations.

Interaction with other medicinal products
are not described.

Form release
Tablets 500 mg.
10 tablets in blisters. 1 or 2 blisters with instruction on use are placed in a pile of cardboard.
Is supposed to stack blisters with an equal number of instructions for use in the packaging group.

Storage conditions
In a dry place at temperatures no higher than 25 ° C. Keep out of the reach of children.

Shelf life
4 years.
Do not use beyond the expiration equipoise results date printed on the package.

Conditions of supply of pharmacies
by prescription. cutting steroids casual clothing for bodybuilders buy test e online bodybuilding workout program

buy equipoise

Communicating with the dihydropyridine receptor blocking “slow” calcium channels inhibits the transmembrane transfer of calcium into the cells of smooth muscles of the heart and blood vessels (mainly – in the vascular smooth muscle cells than cardiac myocytes). It has hypotensive and antianginal effects. The mechanism buy equipoise of the antihypertensive action of amlodipine is due to a direct relaxing effect on vascular smooth muscle. Amlodipine reduces myocardial ischemia following two ways: 1. Extends arterioles and thus, reduces the total peripheral resistance (afterload), the heart rate does not change substantially, resulting in lower energy consumption and myocardial . It extends the coronary and peripheral arteries and arterioles both in normal and in ischemic areas of the myocardium, which increases the supply of oxygen to the myocardium in patients with vasospastic angina (Prinzmetal angina) and prevents the development of coronary spasm induced by smoking. Patients with hypertension single daily dose Kalcheka ® provides reduction of blood pressure (BP) for 24 hours (as in the position of “lying” and “standing”). Due to the slow onset of action of amlodipine does not cause a sharp decrease buy equipoise in blood pressure. In patients with angina single daily dose increases the run-time physical activity, retards the development of the next angina and ST segment depression (1 mm) on the background of physical activity, reduces the frequency of angina attacks and consumption of nitroglycerin  patients with cardiovascular disease (including coronary atherosclerosis with the defeat of the vessel and to the stenosis 3 or more of the arteries and atherosclerosis of the carotid artery), myocardial infarction, percutaneous transluminal angioplasty of the coronary arteries .

Pharmacokinetics
After oral administration of amlodipine slowly absorbed (about 90%) from the gastrointestinal tract. The absolute bioavailability of 64-80%, the maximum concentration in serum is observed after 6-9 hours.The equilibrium concentrations are achieved after 7-8 days of drug therapy. Ingestion of amlodipine does not affect the absorption. The mean volume of distribution of 21 l / kg of body weight, indicating that most of the drug remain in the tissues and relatively smaller -. Blood
Most of the drug present in the blood (97%), bind to plasma proteins.

Contraindications
– Hypersensitivity to amlodnpinu and / or other components of the drug, as well as to other dihydropyridine derivatives;
– severe hypotension buy equipoise (systolic blood pressure less than 90 mm ??Hg),
– unstable angina (except Prinzmetal’s angina)
– pronounced stenosis aorta
– the age of 18 years (effectiveness and safety have been established).

With caution: liver dysfunction, sick sinus syndrome (bradycardia, tachycardia), chronic heart failure, non-ischemic etiology (III-IV functional class NYHA classification), hypotension, aortic stenosis, mitral stenosis, hypertrophic obstructive cardiomyopathy, acute myocardial infarction (and for 1 month after), advanced age.

Pregnancy and lactation
The safety of amlodipine in pregnancy has not been established, therefore use during pregnancy is possible only when the benefit to the mother outweighs risk to the fetus.
There is no evidence of amlodipine buy equipoise excretion in breast milk.
However, it is known that other BCCI – dihydropyridine derivatives are excreted in breast milk. If necessary, amlodipine appointment during lactation should decide the issue of termination of breastfeeding.

Dosing and Administration
Inside, the initial dose for treatment of hypertension and angina is 5 mg 1 time per day. The dose may be as much as possible to be increased to 10 mg once a day.
When hypertension maintenance dose may be 5 mg daily.
Do not need to change the dose while the appointment with thiazide diuretics, beta-blockers or angiotensin-converting enzyme (ACE).
Not required dose modification in patients with renal insufficiency.
in patients with impaired hepatic function dose adjustment is usually not required.
in elderly patients, it is recommended to use in high therapeutic doses, dose adjustment is required.

Side effect On the part of the cardiovascular system: heart rate, marked reduction in blood pressure, peripheral edema (swelling of the ankles and feet), rarely – a violation of cardiac rhythm (bradycardia, ventricular tachycardia, atrial flutter), heart attack, chest pain, orthostatic hypotension, vasculitis, very rare – development or exacerbation of congestive heart failure, arrythmia, migraine. On the part of the central nervous system: headache, dizziness, fatigue, heat sensation and “tides” of blood to the skin of the face, drowsiness, mood changes, seizures, rare – loss consciousness, hypoesthesia, nervousness, paresthesia, peripheral neuropathy, tremor, vertigo, fatigue, malaise, syncope, insomnia, emotional lability, depression, anxiety, abnormal dreams, very rarely – ataxia, apathy, agitation, amnesia. From the digestive system: nausea , vomiting, epigastric pain, rarely – increased activity of “liver” transaminases, hyperbilirubinemia, jaundice (caused by cholestasis), pancreatitis, dry mucous membranes of the mouth, thirst, hepatitis, flatulence, gingival hyperplasia, constipation, diarrhea, anorexia, rarely – gastritis, increased appetite. From the side of hematopoiesis: rarely – thrombocytopenic purpura, leukopenia, thrombocytopenia. The respiratory system: dyspnea, rhinitis, very rarely – cough. With the genitourinary system: rare – pollakiuria, tenesmus, nocturia, sexual dysfunction (including reduced potency); very rarely – dysuria, polyuria. For the skin: very rarely – dermatoxerasia, dermatitis, purpura, violation of skin pigmentation. Allergic reactions: itching, rash (including erythematous, maculopapular rash, urticaria), angioedema, erythema multiforme. From the musculoskeletal system: rarely – arthralgia, muscle cramps, arthritis, back pain, myalgia (with prolonged use); very rarely – myasthenia gravis. The other: seldom – gynecomastia, ginerurikemiya, increase / decrease in body weight, hyperglycemia, impaired vision, diplopia, conjunctivitis, eye pain, tinnitus, dyspnea, epistaxis, increased sweating; very rarely – a cold clammy sweat, parosmiya, taste disturbance, disturbance of accommodation, xerophthalmia.

Overdose Symptoms: marked reduction of blood pressure, tachycardia, excessive peripheral vasodilatation (risk of severe and persistent hypotension, including shock development). Treatment: gastric lavage, the appointment of activated carbon (especially in the first 2 hours after the overdose), the maintenance of cardiovascular function -sosudistoy system control parameters of the heart and lung function, elevated position limbs, control of blood volume and diuresis. To restore vascular tone – use of a vasoconstrictor (in the absence of contraindications to their use); to eliminate the effects of calcium channel blockade – intravenous calcium gluconate. Hemodialysis is ineffective.

Interaction with other medicinal products
can be expected that inhibitors of microsomal liver enzymes will increase plasma amlodipine concentrations, increasing the risk of side effects, and inducers of microsomal liver enzymes -. Reduce
Unlike other BCCI not observed clinically significant interactions with non-steroidal anti-inflammatory drugs, especially with indomethacin.
Thiazide and “loop” diuretics, beta-blockers, verapamil, ACE and nitrate inhibitors increase antianginal and antihypertensive effect of amlodipine.
Amiodarone, quinidine, means for inhalation anesthesia (derivatives of hydrocarbons), alpha 1-blockers, antipsychotic drugs (neuroleptics) and BCCI may enhance the hypotensive effect.
amlodipine has no effect on the pharmacokinetic parameters of digoxin and warfarin.
Cimetidine: while the use of amlodipine with cimetidine pharmacokinetics of amlodipine is not changed.
when combined amlodipine with drugs lithium may increase manifestations of neurotoxicity (nausea, vomiting, diarrhea, . ataxia, tremor, tinnitus)
calcium supplementation may reduce the effect of BCCI.
Antiviral drugs (ritonavir) increase the plasma concentrations of BCCI, including amlodipine.
Isoflurane – strengthen hypotensive action dihydropyridine derivatives.
in a joint application BCCI with drugs lithium may increase neurotoxicity.
Re-administration of amlodipine 10 mg and atorvastatin 80 mg is not accompanied by a significant change in the pharmacokinetics of atorvastatin.
Simultaneous administration of 240 ml greynfrutovogo juice and 10mg amlodipine is not accompanied by significant changes in the pharmacokinetics of amlodipine.
Co-administration of 100 mg of sildenafil in patients with essential hypertension has no impact on the pharmacokinetic parameters of amlodipine.

Cautions
During treatment requires monitoring of body weight and sodium intake, the appointment of an appropriate diet.
It is necessary to maintain dental hygiene and frequent visits to the dentist (to prevent soreness, bleeding and gingival hyperplasia).
The dosage regimen for elderly patients is the same as for patients other age groups. By increasing the dose should be carefully monitored for elderly patients.
Despite the lack of BCCI “cancellation” syndrome, before stopping treatment recommended a gradual reduction in dose.
Amlodipine has no effect on the plasma concentrations of potassium ions, glucose, triglycerides, total cholesterol, low density lipoprotein, uric acid , creatinine, uric acid and nitrogen.
patients with low body weight, patients of small stature, and in patients with severe impaired liver function may need a lower dose.
Efficacy and safety of the drug Kalchek ® has not been established for hypertensive crisis.

Effects on ability to drive vehicles and mechanisms
During treatment caution should be exercised when driving and occupation of other activities that require concentration and speed of psychomotor reactions, because of the possibility of dizziness and drowsiness.

Product form
of 10 or 14 tablets in blisters (blister) aluminum foil and PVC film. 2 blisters containing 14 tablets, or 3 blisters containing 10 tablets in cardboard pack, complete with instructions for use. Buy muscle labs usa online