By reducing doxazosin vascular muscle tone decreases total peripheral vascular resistance which leads to lower blood pressure (BP). After a single ingestion maximum hypotensive effect observed in the period from 2 to six hours, but in general equipoise cycle hypotensive effect is maintained for 24 hours. During treatment with doxazosin in hypertensive patients with no differences quantities of BP in the standing and lying down. It is effective in hypertension, including, accompanied by metabolic disorders (obesity, impaired glucose tolerance). Reduces the risk of developing coronary heart disease. The drug in people with normal blood pressure (BP) is not accompanied by a decrease in blood pressure. With prolonged use of doxazosin in patients with no observed change in tolerance to the therapeutic antihypertensive effect. During treatment with doxazosin a decrease in the level of concentration in the blood plasma triglycerides, total cholesterol. At the same time there is some (4 – 13%) increase in HDL / total ratio equipoise cycle cholesterol. Prolonged treatment doxazosin observed left ventricular hypertrophy regression, inhibition of platelet aggregation and improvement in their tissues active plasminogen. Due to the fact that doxazosin blocks alpha1-adrenergic receptors, located in the stroma and prostatic capsule and bladder neck, there is a decrease of resistance and pressure in the urethra, internal sphincter resistance decrease.
Pregnancy and lactation
Pregnant women can be given the drug only for health reasons, when benefit to the mother outweighs the potential risk to the fetus / baby. Safety of the drug in infants has not been established, therefore, nursing mothers should stop feeding during treatment with doxazosin.
Dosing and Administration
Inside, 1 time a day (morning or evening), regardless of the meal, not chewing and drinking plenty of water.
The dose should be adjusted depending on the efficacy or potential side effects in certain patients. Patients with hepatic impairment require lower doses of the drug due to slow metabolism.
If the patient has forgotten to take the drug at the usual time, it should be as soon as possible to take the proper dose. If it is time for the next dose, you should only accept it (not doubling the dose). It is important to take the drug regularly. If the patient did not take the drug for a few days, the new course of therapy should be started with the lowest dose. Hypertension: The equipoise cycle CL is 1 tablet (4 mg) per day. Its effect can be observed on the first day, the therapeutic effect occurs within 4 weeks after starting treatment. After 4 weeks, in case of good tolerability and if the doctor considers the effect of higher doses may be administered insufficient. The maximum recommended daily dose of Camiri ® CL is 2 tablets (8 mg) in one go. If the therapeutic effect is not sufficient, patients may simultaneously receive other antihypertensive agents: beta-blockers, diuretics, blockers “slow” calcium channel blockers and ACE inhibitors. After reaching a stable the therapeutic effect of the dose is usually somewhat lower (average therapeutic dose for maintenance therapy is usually 2-4 mg per day), you can go to the reception Camiri, tablets of 2 or 4 mg. Benign prostatic hyperplasia in patients with normal blood pressure: the usual dose is 1 tablet (4mg) Camiri ® CL per day. The patient should take the first dose in the evening before bedtime. Depending on the drug, the dose can be gradually increased at intervals of 1-2 weeks up to 8 mg once daily. Typically, the average daily dose range from 2 mg to 4 mg, can go to the reception Camiri tablets equipoise cycleat 2 or 4 mg maximum daily dose of 8 mg. Benign prostatic hyperplasia in hypertensive patients: dose are the same as in case of hypertension without benign prostatic hyperplasia (see. dose in hypertension). The drug is used for a long time. Duration of treatment is determined by the attending physician.
Side effects Hypertension frequently observed in clinical trials, especially in the beginning of treatment, orthostatic hypotension, which in rare cases may cause fainting. Common reactions: asthenia, fatigue, malaise. Cardio-vascular system: . Swelling, fainting eliminating alpha -adrenostimuliruyuschie effects of epinephrine may cause tachycardia and hypotension.
Particular caution should be exercised in the appointment of the drug to patients with impaired liver function, especially in those cases where both are used drugs that can affect the liver. In case of deterioration of the functional state of the liver drug overturned immediately.
In order to prevent orthostatic reactions, patients should avoid unexpected and sudden shifts in body position (transition from the “lying” to “standing”).
Drinking alcohol can increase adverse reactions.
Safety and efficacy of doxazosin in children has not been established, so it is not recommended to prescribe a drug for children.
The effect of the “first” of the drug is especially pronounced against the background of previous diuretic therapy and dietary sodium restriction.
Before therapy is necessary to exclude malignant degeneration of the prostate. prostate
due to the fact that doxazosin is capable cause orthostatic reactions at the beginning of treatment or during the period of increasing dosages to patients it is advisable to refrain from any potentially dangerous activities, in particular from road transport management and other vehicles and machinery.
tablets with modified release of 4 mg. 10 tablets in a blister pack. 1, 3 or 9 blisters in a carton box together with instructions for use.
Store at a temperature not exceeding 25 ° C.
Keep out of reach of children.
2 years. Do not use after the expiration date printed on the package.